Does therapeutic angiogenesis overcome CKD?
نویسندگان
چکیده
منابع مشابه
Therapeutic angiogenesis.
Therapeutic angiogenesis constitutes a fundamental survival mechanism that acts to preserve the integrity of tissues subjected to ischemia. Supplemental administration of angiogenic cytokines--as recombinant protein or plasmid DNA--have been shown to augment collateral development when endogenous angiogenesis is suboptimal for organ function, and thus constitute a novel therapeutic option for t...
متن کاملTherapeutic Angiogenesis
Vascular endothelial growth factor (VEGF) is a heparin-binding, endothelial cell-specific mitogen. Previous studies have suggested thatVEGF is a regulator ofnaturally occurring physiologic and pathologic angiogenesis. In this study we investigated the hypothesis that the angiogenic potential of VEGF is sufficient to constitute a therapeutic effect. The soluble 165amino acid isoform ofVEGF was a...
متن کاملDoes the greater omentum ("policeman of the abdomen") possess therapeutic utility in CKD?
CKD is a progressive disorder that results in ESRD, requiring chronic hemodialysis or a kidney transplant, and affects 400 million individuals globally and 36 million individuals in the United States.1 In up to 50% of all cases, CKD is caused by diabetic nephropathy (DN).2,3 CKD per se and its associated and progressive cardiovascular comorbidities constitute a major health burden for affected ...
متن کاملDoes AKI truly lead to CKD?
Acute kidney injury (AKI) has been implicated as an independent risk factor for the development of CKD in recent observational studies. The presumption in the nephrology community is that this association represents a causal relationship. However, because of potential problems related to residual confounding (shared risk factors), ascertainment bias (sicker patients have more follow-up assessme...
متن کاملDoes calcium disodium EDTA slow CKD progression?
G iven the increasing incidence and prevalence of chronic kidney disease (CKD), approaches to slow disease progression are essential. For more than a decade, Ja-Liang Lin and colleagues have published randomized placebo-controlled clinical trials reporting that treatment with calcium disodium EDTA slows CKD progression. Lead chelation has been implicated as the mechanism, and benefits in diabet...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension Research
سال: 2009
ISSN: 0916-9636,1348-4214
DOI: 10.1038/hr.2009.208